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Inventi Impact: Molecular Pharmacology

Articles

  • Inventi:pmp/18528/16
    Role of Mas Receptor Antagonist A799 in Renal Blood Flow Response to Ang 1-7 after Bradykinin\nAdministration in Ovariectomized Estradiol-treated Rats
    01-Jan-1970 Research 2016 : January - March
    Aghdas Dehghani, Shadan Saberi, Mehdi Nematbakhsh

    Background.The accompanied role of Mas receptor (MasR), bradykinin (BK), and female sex hormone on renal blood flow (RBF)\nresponse to angiotensin 1-7 is not well defined.We investigated the role ofMasR antagonist (A779) and BK on RBF response to Ang\n1-7 infusion in ovariectomized estradiol-treated rats. Methods.Ovariectomized Wistar rats received estradiol (OVE) or vehicle (OV)\nfor two weeks. Catheterized animals were subjected to BK and A799 infusion and mean arterial pressure (MAP), RBF, and renal\nvascular resistance (RVR) responses to Ang 1-7 (0, 100, and 300 ng kgâË?â??1 minâË?â??1) were determined. Results. Percentage change of RBF\n(%RBF) in response to Ang1-7 infusion increased in a dose-dependentmanner. In the presence of BK, when MasR was not blocked,\n%RBF response to Ang 1-7 in OVE group was greater than OV group significantly (

    How to Cite this Article
    CC Compliant Citation: Aghdas Dehghani, Shadan Saberi, and Mehdi Nematbakhsh, â??Role of Mas Receptor Antagonist A799 in Renal\nBlood Flow Response to Ang 1-7 after Bradykinin Administration in Ovariectomized Estradiol-Treated Rats,â? Advances in\nPharmacological Sciences, vol. 2015, Article ID 801053, 9 pages, 2015. doi:10.1155/2015/801053, http://creativecommons.org/\nlicenses/by/3.0/.
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